خرید و دانلود نسخه کامل کتاب The MicroRNA Quantum Code Book – Original PDF

The RNA Wave 2000 MicroRNAs (miRNAs) have been identified as a major class of human small RNAs, single-stranded RNAs, 21–25 nucleotides (nts) in length. The 3′ untranslated regions (UTRs) of messenger RNAs (mRNAs) are targeted by miRNAs through imperfect base pairing (Fujii 2017). Although we discovered miRNAs (Omoto and Fujii 2006; Fujii 2017), it is now well known that resident miRNAs repress gene expression at the translational and transcriptional levels. miRNAs as noncoding genes (genomic miRNAs) are transcribed from intergenic and intronic regions, and also the protein- coding sites (CDS) of the human genome (as DNA) and RNA virus genome. miR- NAs in exosome are mobile genetic elements because they are secreted from cells We only see what we know. —von Goethe JW © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023 Y. R. Fujii, The MicroRNA Quantum Code Book, https://doi.org/10.1007/978-981-19-8586-7_1 2 Fig. 1.1 Preparation of idea for miRNA function analysis into circulation, horizontally transmitted to other cells, and vertically transmitted from mother to fetus. Below is a validated RNA wave 2000 model (Fujii 2008, 2017). (1) miRNA genes are mobile genetic elements that induce transcriptional and posttranscriptional silencing through network processes. (2) RNA information provided by miRNA genes is affected by the global environment and the life cycles and spreads intracellularly, intercellularly, intraorganically, interorganically, in intraspecies, and in interspecies. (3) Mobile miRNAs are self-propagating and (4) cells contain resident and genomic miRNAs. Therefore, we hypothesized that most of all biological processes, including human diseases, are programmed and con- trolled by the miRNA code (Fig. 1.1). Elements required for elucidation of the quantum miRNA code are indicated in Fig. 1.1 (numbers 1–7). Among them, the elements related to computer science account for Nos. 3–7, and the key is Nos. 1 and 2, miRNA biology, and genetics. That is where data bioscience is different from simple data science.