خرید و دانلود نسخه کامل کتاب Glycosignals in Cancer – Original PDF

The Ganglioside Ceramide Structures Ceramides are N-acylated long-chain aliphatic amino alcohols called sphingoids. The most commonly occurring sphingoid is the unsaturated compound (2S,3R,4E)-2-aminooctadec-4-ene-1,3-diol, worldwide reported as d18:1 or C18-sphingosine (Carter et al. 1947; Karlsson 1970; Carter et al. 1961). The corresponding saturated compound originally named “dihydrosphingosine” should now be as sphinganine, C18-sphinganine, or d18:0. Figure 4 shows the correct representation for a 2S,3R,4E sphingoid (Fig. 4a) and the corresponding ceramide (Fig. 4b). The second more abundant mammalian sphingoid contains 20 carbon atoms, the eicosasphingosine, or d20:1 or C20-sphingosine. The fatty acids of naturally occurring ceramides range in chain length from about C16 to about C 26 and may contain one or more double bonds and/or hydroxyl substituents at C-2. The fatty acid linked to the sphingosine of the nervous system